This page contains spoilers about the Heartbound ARG. If you want to solve the puzzle yourself, avoid reading this article.
Currently, very little is known about Guardian Glyphs. Binder and Lore have both been seen casting spells while "speaking" in them. The villagers of Animus have been seen writing in them (on the Teespring t-shirts), as has the author of the pages in The Spine, that presumably being Binder.
If you enter the following code before starting the game, you'll hear a faint laughter, and the in-game guardian glyphs will be translated for you: